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Corine Bertolotto Selected Research

Microphthalmia-Associated Transcription Factor

1/2022MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells.
1/2021ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity.
12/2020The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?
2/2019Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma.
1/2017Deregulated MITF sumoylation: A route to melanoma.
11/2016FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells.
6/2014Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma.
1/2014A germline oncogenic MITF mutation and tumor susceptibility.
10/2011A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.
5/2010Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas.
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Corine Bertolotto Research Topics

Disease

49Melanoma (Melanoma, Malignant)
01/2022 - 07/2005
23Neoplasms (Cancer)
09/2021 - 02/2007
5Neoplasm Metastasis (Metastasis)
12/2021 - 08/2010
3Uveal melanoma
12/2021 - 01/2020
2Hyperpigmentation
11/2020 - 10/2014
2Type 2 Diabetes Mellitus (MODY)
10/2014 - 05/2009
2Hypoxia (Hypoxemia)
10/2011 - 07/2005
2Carcinogenesis
10/2011 - 02/2007
1Skin Neoplasms (Skin Cancer)
01/2019
1Vitiligo
01/2019
1Colorectal Neoplasms (Colorectal Cancer)
11/2018
1Nevus (Nevi)
01/2017
1Carcinoma (Carcinomatosis)
10/2016
1Necrosis
12/2011
1Kidney Neoplasms (Kidney Cancer)
10/2011
1Disease Progression
08/2010
1Prostatic Neoplasms (Prostate Cancer)
03/2010
1Oculocutaneous albinism type 2
07/2009
1Type IV Oculocutaneous Albinism
07/2009

Drug/Important Bio-Agent (IBA)

12Microphthalmia-Associated Transcription FactorIBA
01/2022 - 07/2005
8Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2005
6Pharmaceutical PreparationsIBA
06/2020 - 08/2012
5Transcription Factors (Transcription Factor)IBA
01/2021 - 10/2011
5VemurafenibIBA
06/2020 - 08/2012
4Biological ProductsIBA
11/2021 - 07/2005
3CaspasesIBA
01/2020 - 09/2005
3Metformin (Glucophage)FDA LinkGeneric
10/2014 - 03/2010
2Small Interfering RNA (siRNA)IBA
01/2022 - 02/2007
2Biomarkers (Surrogate Marker)IBA
12/2021 - 01/2021
2Immunologic Factors (Immunomodulators)IBA
01/2021 - 01/2021
2IntegrinsIBA
01/2021 - 11/2018
2ChemokinesIBA
02/2019 - 06/2011
2SphingolipidsIBA
01/2019 - 01/2019
2EnzymesIBA
01/2019 - 01/2018
2Nicotinamide PhosphoribosyltransferaseIBA
12/2018 - 01/2018
2NAD (NADH)IBA
12/2018 - 01/2018
2Fibronectins (Fibronectin)IBA
11/2018 - 02/2007
2Adapalene (Differin)FDA LinkGeneric
01/2015 - 07/2014
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
08/2012 - 02/2007
2Messenger RNA (mRNA)IBA
08/2010 - 07/2005
2LigandsIBA
05/2009 - 06/2008
2alpha-MSHIBA
05/2007 - 07/2005
1Protein Kinases (Protein Kinase)IBA
01/2022
1Immune Checkpoint InhibitorsIBA
09/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1AntigensIBA
12/2020
1Large Neutral Amino Acid-Transporter 1IBA
11/2020
1Skin Lightening PreparationsIBA
11/2020
1panicein AIBA
06/2020
1hydroquinone (Esoterica)FDA Link
06/2020
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2020
1navitoclaxIBA
01/2020
1Histones (Histone)IBA
01/2020
1Protein Isoforms (Isoforms)IBA
01/2019
1Interferon-gamma (Interferon, gamma)IBA
01/2019
1ABT-737IBA
01/2019
1Acid CeramidaseIBA
01/2019
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
01/2019
1Niacinamide (Nicotinamide)FDA LinkGeneric
01/2019
1CeramidesIBA
01/2019
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2018
1Zinc Finger E-box-Binding Homeobox 1IBA
10/2016
1Endoplasmic Reticulum Chaperone BiPIBA
01/2016
1NF-kappa B (NF-kB)IBA
01/2015
1ElementsIBA
10/2014
1Carrier Proteins (Binding Protein)IBA
10/2014
1Melanins (Melanin)IBA
10/2014
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
06/2014
1pigment epithelium-derived factorIBA
06/2014
1Imatinib Mesylate (Gleevec)FDA Link
05/2014
1Sirtuin 1IBA
04/2014
19-deoxy-delta-9-prostaglandin D2IBA
03/2014
1Mitogen-Activated Protein KinasesIBA
08/2012
1DNA (Deoxyribonucleic Acid)IBA
12/2011
1Sorafenib (BAY 43-9006)FDA Link
12/2011
1Dacarbazine (DIC)FDA LinkGeneric
12/2011
1Mutant Proteins (Protein, Mutant)IBA
10/2011
1Transforming Growth Factor beta (TGF-beta)IBA
08/2010
1Cadherins (E-Cadherin)IBA
08/2010
1Matrix Metalloproteinases (MMPs)IBA
08/2010
1matrigelIBA
08/2010
1Adenylate KinaseIBA
03/2010
1Caspase 3 (Caspase-3)IBA
03/2010
1Deoxyglucose (2 Deoxy D glucose)IBA
03/2010
1Adenosine Triphosphate (ATP)IBA
03/2010
1ciglitazoneIBA
05/2009
1Rosiglitazone (Avandia)FDA Link
05/2009
1ThiazolidinedionesIBA
05/2009
1PPAR gammaIBA
05/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2008
1StaurosporineIBA
06/2008
1SurvivinIBA
06/2008
1Proto-Oncogene Proteins c-metIBA
05/2007
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2007
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
05/2007
1MitogensIBA
02/2007
1Phosphotransferases (Kinase)IBA
02/2007

Therapy/Procedure

16Therapeutics
01/2022 - 03/2010
6Immunotherapy
12/2021 - 01/2018
3Drug Therapy (Chemotherapy)
07/2014 - 04/2011